SLADE LAB PUBLICATIONS

All Publications

17. Casasanta, M.A., Yoo, C.C., Smith, H.B., Duncan, A.J., Cochrane, K., Varano, A.C., Allen-Vercoe, E., Slade, D.J., 2017. A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum. J. Biol. Chem. Epub ahead of print.
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Previously posted on BiorXiv

16. Ghavami, M., Merino, E.F., Yao, Z.-K., Elahi, R., Simpson, M.E., Fernández-Murga, M.L., Butler, J.H., Casasanta, M.A., Krai, P.M., Totrov, M.M., Slade, D.J., Carlier, P.R., Cassera, M.B., 2017. Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs. ACS Infect Dis.
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15. Balhouse, B.N., Patterson, L., Schmelz, E.M., Slade, D.J., Verbridge, S.S., 2017. N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro. PLoS One 12, e0180372.
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Previously Posted on BiorXiv

14. Rothschild DE, Zhang Y, Diao N, Lee CK, Chen K, Caswell CC, Slade DJ, Helm RF, LeRoith T, Li L, Allen IC. Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M. EBioMedicine. 2016. Epub 2016/12/13. doi: 10.1016/j.ebiom.2016.11.039. PubMed PMID: 27939424.
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13. Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR. Chemical Proteomic Platform To Identify Citrullinated Proteins. ACS Chem Biol. 2015;10(11):2520-8. Epub 2015/09/12. doi: 10.1021/acschembio.5b00438. PubMed PMID: 26360112; PMCID: PMC4729336.
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12. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rudiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015;11(3):189-91. Epub 2015/01/27. doi: 10.1038/nchembio.1735. PubMed PMID: 25622091; PMCID: PMC4397581.
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PDB: 4X8C | PDB: 4X8G |

11. Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem Biol. 2015;10(4):1043-53. Epub 2015/01/27. doi: 10.1021/cb500933j. PubMed PMID: 25621824; PMCID: PMC4569063.
Full Text and PDF | Cover of ACS Chemical Biology | C&EN feature

PDB: 4N20 | PDB: 4N22 | PDB: 4N24 | PDB: 4N25 | PDB: 4N26 | PDB: 4N28 | PDB: 4N2A | PDB: 4N2B | PDB: 4N2C | PDB: 4N2D | PDB: 4N2E | PDB: 4N2F | PDB: 4N2G | PDB: 4N2H | PDB: 4N2I | PDB: 4N2K | PDB: 4N2L | PDB: 4N2M | PDB: 4N2N |

10. Slade DJ, Horibata S, Coonrod SA, Thompson PR. A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. Bioessays. 2014;36(8):736-40. Epub 2014/06/04. doi: 10.1002/bies.201400057. PubMed PMID: 24889365; PMCID: PMC4151298.
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9. Slade DJ, Subramanian V, Thompson PR. Pluripotency: citrullination unravels stem cells. Nat Chem Biol. 2014;10(5):327-8. Epub 2014/04/20. doi: 10.1038/nchembio.1504. PubMed PMID: 24743255; PMCID: PMC4632640.
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8. Slade DJ, Subramanian V, Fuhrmann J, Thompson PR. Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers. 2014;101(2):133-43. Epub 2013/04/12. doi: 10.1002/bip.22256. PubMed PMID: 23576281; PMCID: PMC3900596.
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7. Rohrbach AS, Slade DJ, Thompson PR, Mowen KA. Activation of PAD4 in NET formation. Front Immunol. 2012;3:360. Epub 2012/12/25. doi: 10.3389/fimmu.2012.00360. PubMed PMID: 23264775; PMCID: PMC3525017.
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Featured in the book NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology

6. Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation. Proc Natl Acad Sci U S A. 2012;109(33):13331-6. Epub 2012/08/03. doi: 10.1073/pnas.1203280109. PubMed PMID: 22853951; PMCID: PMC3421185.
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5. Fixen KR, Janakiraman A, Garrity S, Slade DJ, Gray AN, Karahan N, Hochschild A, Goldberg MB. Genetic reporter system for positioning of proteins at the bacterial pole. MBio. 2012;3(2). Epub 2012/03/01. doi: 10.1128/mBio.00251-11. PubMed PMID: 22375072; PMCID: PMC3302567.
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4. Slade DJ, Lovelace LL, Chruszcz M, Minor W, Lebioda L, Sodetz JM. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. J Mol Biol. 2008;379(2):331-42. Epub 2008/04/29. doi: 10.1016/j.jmb.2008.03.061. PubMed PMID: 18440555; PMCID: PMC2443722.
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PDB: 2RD7

3. Lovelace LL, Chiswell B, Slade DJ, Sodetz JM, Lebioda L. Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding. Mol Immunol. 2008;45(3):750-6. Epub 2007/08/19. doi: 10.1016/j.molimm.2007.06.359. PubMed PMID: 17692377.
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PDB: 2QOS

2. Chiswell B, Slade DJ, Sodetz JM. Binding of the lipocalin C8gamma to human complement protein C8alpha is mediated by loops located at the entrance to the C8gamma ligand binding site. Biochim Biophys Acta. 2006;1764(9):1518-24. Epub 2006/08/29. doi: 10.1016/j.bbapap.2006.07.003. PubMed PMID: 16935577.
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1. Slade DJ, Chiswell B, Sodetz JM. Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9. Biochemistry. 2006;45(16):5290-6. Epub 2006/04/19. doi: 10.1021/bi0601860. PubMed PMID: 16618117.
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